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22, n o 6, 343–352 (ISSN 0263-6484, PMID 15386533, DOI 10.1002/cbf.1149, lire en ligne, consulté le ↑ Nutrition Reviews 54: 1–30, 1996 ↑ Clinical Science 91: 575–582, 1996 ↑ American Journal of Medical Science 307: 119–127, 1994 ↑ Gut 42: 492, 1998 ↑ American Journal of Gastroenterology 91: 2569–2573, 1996 ↑ Nephron 61: 404–408, 1992 ↑ Early Human Development 37: 167–174, 1994 ↑ (en) Hinson JA, Andrews LS, Gillette JR., « Kinetic evidence for multiple chemically reactive intermediates in the breakdown of phenacetin N-O-glucuronide
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Intranasal administration of the optimized formulation (Cmax = ~ 600 ng/mL, tmax = 0.5 h) exhibited a plasma AUC 0.78 times the AUC of the orally administered product (Cmax = ~ 780 ng/mL, tmax = 2 h), whereas the brain AUC was significantly (3.28 times) higher for intranasal administration (Cmax = ~1240 ng/mL, tmax = 0.5 h) than oral administration (Cmax = ~ 380 ng/mL, tmax = 1 h)
